Exercise book on Aromatic Nitrogen Heterocycles Chemistry, How to deal with the synthesis and reactivity of five- and six-membered rings
EDP sciences
Date de publication
Current Natural Sciences

Exercise book on Aromatic Nitrogen Heterocycles Chemistry

How to deal with the synthesis and reactivity of five- and six-membered rings

EDP sciences

Current Natural Sciences


Autre version disponible

Heterocyclic chemistry is one of the largest branches of chemistry.
Heterocycles play major roles in important fields such as medicinal and
pharmaceutical chemistries, agrochemicals or polymers. A good understanding of
the comparative reactivity of simple five- and six-membered rings, i.e.
pyrrole vs pyridine type rings, makes it possible to approach or predict the
reactivity of more complex heterocycles. This book is a compilation of
exercises, mostly adapted from published works. For more clarity we have
chosen to limit ourselves to nitrogen containing heterocycles. The book is
mainly aimed to Master students, but it will also be of interest for anyone
who wants to train in this important field of synthetic chemistry. The book is
organized in five sections. In the first chapter, typical syntheses along with
metal catalyzed pathways are presented. The two following chapters are devoted
to the chemical reactivity of the six-membered (pyridine, quinoline, azines)
and five-membered rings (pyrrole, indole, azoles). In these two chapters, the
exercises of increasing difficulties focus on the main types of reactions,
including electrophilic and nucleophilic aromatic substitutions, N-alkylation
and N-arylation, lithiation and other organometallic reactions, and metal
catalyzed cross-coupling reactions. In the fourth chapter, the principles
discussed in the previous chapters will be applied to the chemistry of complex
polycyclic heterocycles containing both five and six membered rings (pyrrolyl-
pyridine, aza-indole, indolizine, purine). The exercise solutions are
commented in a separate chapter at the end of the book. Basic notions of
nomenclature are given in a short appendix, allowing students to find out a
ring structure from its name.
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